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HLAB27 Test

What is HLAB27 Test?

HLAB27 is used in the diagnosis of an auto-immune disorder such as ankylosing spondylitis, reactivate arthritis and rheumatoid arthritis in children which is termed juvenile rheumatoid arthritis.

Why take HLAB27 Test?

Autoimmune disorders like ankylosing spondylitis, reactive arthritis is progressive in nature. Symptoms typically start in the early 30’s but effects are visually seen on an x-ray after many years. The symptoms start out subtle and gradually develop over the years. This test helps determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells and in turn it helps assess the likelihood that you may be suffering from an autoimmune disorder.

Is this for you?

The doctor may order the test for you if you display the following symptoms

  • Pain, inflammation associated with stiffening of spine, neck and chest may indicate ankylosing spondylitis.
  • Inflammation of the joints and skin lesions

More about HLAB27 Test

HLA-B27 is a specific protein that is found on cell surfaces. The HLAB27 is used to identify the presence or absence of this protein on white blood cells. The full form of HLA is Human Leukocyte Antigen and helps the body identify between its own cells and foreign body. People with HLA-B27 have an increased likelihood of developing autoimmune diseases such as ankylosing spondylitis, reactive arthritis, juvenile rheumatoid arthritis and isolated acute anterior uveitis. HLAB27 is also associated with Inflammatory Bowel Disease.

Reference Values

A negative test means that there is no HLA-B27 in your blood. It is important to note that a negative HLA-B27 test does not mean that you may not have an autoimmune disorder. Your doctor will make a final diagnosis basis the symptoms that you have, and test results and he may order more tests if needed.
A positive test results indicates presence of HLA-B27 in your blood.


The person tested is at increased risk of developing certain autoimmune diseases if the test is positive. If it is negative, then the marker was not detected. However even if the test is negative the person may acquire HLA-B27 antigen and develop these autoimmune diseases.

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Pre-Test Information
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