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ROS1 with reflex to FISH if equivocal or positive

Description- This test helps in detection of ROS fusion proteins by immunohistochemistry (IHC) using ROS1 clone D4D6 on FFPE tumor tissue. This test reflexes to FISH for confirmation if IHC result is equivocal. This test helps in determining the eligibility for tyrosine kinase inhibitor (TKI) (eg, crizotinib) therapy, primarily in individuals with pulmonary adenocarcinomas. This test helps in detecting ROS1 fusion proteins (IHC) and ROS1 gene rearrangements (FISH).

Methodology: Immunohistochemistry

 

TAT: 3-5 days

 

Specimen Preparation
Collect - tissue /or cell
Specimen Preparation- formal fix (10 % neutral buffered formalin) and paraffin enter specimen (FFPE specimens square measure needed). shield paraffin block or slides from uncontrolled heat. Transport tissue block or five unstained (3-micron thick sections), charged slides during a tissue transport kit. (Min: a pair of slides). If causing precut slides, don't over heat it.
Storage/Transport Temperature- At temperature or cold. Transport it in cooled instrumentation throughout weather.
Unacceptable conditions- i) Specimens submitted with non-marked/tagged tissue sort square measure rejected.
ii) Depleted specimens aren't tested.
Stability- i) Ambient: Indefinitely;
ii) Refrigerated: Indefinitely;
iii) Frozen: Unacceptable

 

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