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BCL2 (18q21.3) Gene Rearrangement

DESCRIPTION this test is used to detect BCL2 gene rearrangement in B-cell lymphocytes. Its important to study the BCL2 gene rearrangement for differential diagnosis of non-Hodgkin’s lymphomas. Research has revealed that FISH assay (segregation-based) is the better method as compared to PCR to detect the BCL2 gene mutation as it detects 100% of BCL2 arrangement.

CLINICAL UTILITYBCL2 is a proto-oncogene, which is originally discovered at the chromosomal breakpoint of the t (14;18) in follicular lymphoma, which regulates apoptosis also known as programmed cell death inhibition of apoptosis may become the cause for the development of tumors.

METHODOLOGY fluorescence in situ hybridization (FISH)

TURN AROUND TIME 12 days after sample reaches the lab

PATIENT PREPARATION –

COLLECT

– non diluted bone marrow aspirate

SPECIMEN PREPARATION

– add 3ml of bone marrow to sodium heparin or add 5ml of whole blood

STORAGE OR TRANSPORT TEMPERATURE

– room

temperature

(8

-25 degrees C)

STABILITY

– ambient:

48 hours; refrigerated: 48 hours

UNACCEPTABLE CONDITIONS

clotted specimens

MRP 8000

SPECIAL INSTRUCTIONS clinical history is mandatory, please bring your previous health reports with you.

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Get Report In
7 Days
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Pre-Test Information
Clinical History is Mandatory
4,000.00
Home Collection-
Offer Price4,000.00
Total Amount₹4,000.00
*inclusive of all the taxes, fees and subject to availability

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