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Triple Marker Test Helps Identify High-Risk Pregnancies for Fetal Abnormalities

Triple Marker Test Helps Identify High-Risk Pregnancies for Fetal Abnormalities

Mar 2023

The triple marker test (TMT) is a screening test that is used during pregnancy to detect the risk of certain fetal abnormalities, such as Down syndrome, neural tube defects, and abdominal wall defects. It is also sometimes referred to as the Triple Screen Test or the Multiple Marker Screening.
 

The test involves a simple blood draw from the pregnant woman, typically between 15 and 20 weeks of gestation. The blood sample is then analyzed for the levels of three substances: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3).
 

Abnormal levels of these substances may indicate a higher risk of fetal abnormalities. For example, low levels of AFP may indicate the possibility of Down syndrome, while high levels of AFP may indicate the possibility of neural tube defects.

It's important to note that the triple marker test is not a definitive diagnosis of fetal abnormalities, but rather a screening tool that can help identify pregnancies that may be at higher risk. If the test results suggest an increased risk, further diagnostic tests such as amniocentesis may be recommended.

It's also important to keep in mind that not all fetal abnormalities can be detected through the Triple Marker Test, and false positives and false negatives can occur. It's important to discuss the results with a healthcare provider and to understand the limitations and risks of the test.

Triple Marker Test In Pregnancy

The triple marker test, also known as the Triple Screen Test, is a blood test typically performed during the second trimester of pregnancy, between 15 and 20 weeks. The test measures the levels of three substances in the mother's blood: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3).

AFP is a protein produced by the fetus that is normally found in the mother's blood. Abnormal levels of alpha feto protein can indicate the possibility of neural tube defects, such as spina bifida or anencephaly.

hCG is a hormone produced by the placenta that is also found in the mother's blood during pregnancy. Abnormal levels of hCG can indicate the possibility of Down syndrome or other chromosomal abnormalities.

uE3 is a form of estrogen produced by the fetus and placenta. Low levels of uE3 can indicate the possibility of Down syndrome, while high levels can indicate a lower risk of fetal abnormalities.

The results of the Triple Marker Test can help identify pregnancies that may be at higher risk of certain fetal abnormalities. However, it's important to keep in mind that the test is not a definitive diagnosis, and false positives and false negatives can occur.

If the results of the test indicate an increased risk of fetal abnormalities, further diagnostic tests may be recommended, such as amniocentesis. It's important to discuss the results of the Triple Marker Test with a healthcare provider and to understand the limitations and risks of the test.

Triple Marker Test Normal Values

The normal values for the Triple Marker Test can vary slightly depending on the laboratory that performs the test, as well as the gestational age of the pregnancy. However, here are some general ranges for the three substances measured in the test:

  • Alpha-fetoprotein (AFP): 10-150 ng/mL
  • Human chorionic gonadotropin (hCG): 10-200 mIU/mL
  • Unconjugated estriol (uE3): 0.5-3.0 ng/mL

It's important to keep in mind that the normal ranges can vary depending on the gestational age of the pregnancy, and abnormal values do not necessarily mean that there is a problem with the pregnancy. Abnormal values may indicate the need for further testing to evaluate the possibility of certain fetal abnormalities. It's important to discuss the results of the Triple Marker Test with a healthcare provider to understand what the results mean for your specific pregnancy.

Triple Marker Test Price

The price of the triple marker test price can vary depending on several factors, including the location of the testing facility, the specific laboratory that performs the test, and whether the test is covered by insurance.

In the United States, the cost of the test can range from around Rs. 2100 or more, depending on these factors. Some insurance plans may cover the cost of the test, while others may require a copay or coinsurance payment.

It's important to check with your healthcare provider and your insurance company to understand the costs and coverage options for the Triple Marker Test. Some healthcare providers may offer the test as part of a prenatal screening package, which can help reduce the overall cost of testing.

CNC PATH LAB is one of the best healthcare facilities in Delhi and offers the Triple Marker Test as part of prenatal screening for fetal abnormalities. The cost of the Triple Marker Test in Delhi can vary depending on the specific facility and location. It's important to check with the healthcare facility or laboratory directly for information on the cost and availability of the test. Additionally, it's recommended to consult with a healthcare provider for guidance on prenatal screening and testing options.