Mpn Pannel 10

DESCRIPTION – MPN stands for myeloproliferative neoplasms. this test detects mutations in JAK2, CALR and MPL genes using DNA extracted from blood or bone marrow

COMPONENTS – BCR-ABL quantitative, JAK2 exon 12-15, FGFR1, PDGFRA, PDGFRB

METHODOLOGY - fluorescence in situ hybridization (FISH), real-time polymerase chain reaction (real-time PCR) or next generation sequencing (NGS)

TURN AROUND TIME – 12 days

PATIENT PREPARATION –

COLLECT – non diluted bone marrow aspirate

SPECIMEN PREPARATION – 3-4 ml bone marrow or peripheral blood in green top (sodium heparin) or lavender top (EDTA) tube

STORAGE/TRANSPORT TEMPERATURE – 2-8 degrees C (with cold pack)

STABILITY – ambient: 48 hours; refrigerated: 48 hours

UNACCEPTABLE CONDITIONS – clotted specimens

MRP – 15000

SPECIAL INSTRUCTIONS – clinical history is mandatory