MET

DESCRIPTION – MET is a growth receptor for tyrosine kinase. MET gene makes a protein which sends signals within cells and in cell growth and survival. MET gene amplifies and makes extra copies of MET gene which causes uncontrollable growth and leads to cancer.

CLINICAL UTILITY – for NSCLC patients developed resistance against TKI and the crizotinib therapy. Screening test for MET gene amplification.

METHODOLOGY – fluorescence in situ hybridization (FISH)

TURN AROUND TIME – 6 days

PATIENT PREPARATION –

COLLECT – tumor tissue

SPECIMEN PREPARATION – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat

STORAGE/TRANPORT TEMPERATURE – room temperature (8-25 degrees C)

STABILITY – ambient: indefinitely; refrigerated: indefinitely

UNACCEPTABLE CONDITIONS – alternate fixatives and decalcified specimens

MRP – 7000.00

SPECIAL INSTRUCTIONS – clinical history is mandatory including surgical pathology reports