Aml Pannel With Mll

CLINICAL UTILITY – acute myeloid leukemia (AML) is one of the most common leukemia and also comprises 15% of pediatric acute leukemia. This assay helps to identify cytogenetic abnormalities in patients with myeloid malignances and tracking response to therapies. Detection of abnormal clone indicates a diagnosis of AML of various subtypes.

METHODOLOGY – fluorescence in situ hybridization (FISH) or next generation sequencing (NGS)

TURN AROUND TIME – 6 days

PATIENT PREPARATION –

COLLECT – non diluted bone marrow aspirate or whole blood in sodium heparin

SPECIMEN PREPARATION - 3-4 ml bone marrow in sodium heparin or peripheral blood / EDTA (lavender top) tube

STORAGE/TRANSPORT TEMPERATURE – 2-8 degrees C (with cold pack) and transport within 72 hours

STABILITY – ambient: 48 hours; refrigerated: 48 hours

UNACCEPTABLE CONDITIONS – clotted specimens

MRP – 12000

SPECIAL INSTRUCTIONS – clinical history is mandatory including histopathological reports