DESCRIPTION – ROS 1 gene is located at 6q22. ROS 1 is a receptor of tyrosine kinase. The ROS 1 gene fuses with part of another gene and activates ROS 1 gene which causes uncontrolled cell growth and leads to cancer.
CLINICAL UTILITY – to identify NSCLC patients who can benefit from crizotinib therapy
METHODOLOGY – fluorescence in situ hybridization (FISH)
TURN AROUND TIME – 6 days
PATIENT PREPARATION –
COLLECT – tumor tissue
SPECIMEN PREPARATION – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat.
STORAGE/TRANSPORT TEMPERATURE – room temperature (8-25 degrees C)
STABILITY – ambient: indefinitely; refrigerated: indefinitely
UNACCEPTABLE CONDITIONS - alternate fixatives and decalcified specimens
MRP – 7000.00
SPECIAL INSTRUCTIONS – clinical history is mandatory including surgical pathology report
Clinical History is Mandatory.