Description- Expression of ATRX is employed as a diagnostic tool in cancer pathologic process and within the diagnosing of neurogliacyte gliomas. Its specificity associate degreed prevalence in lower-grade gliomas with an IDH mutation argue for thorough characterization of associated sign networks to facilitate therapeutic development.; Mutation or loss of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) expression has been delineated in dysplasia gliomas. ATRX loss may be a hallmark of neurogliacyte tumors and defines a subgroup of neurogliacyte tumors with a positive prognosis.
TAT: 3-5 days
Collect - tissue /or cell
Specimen Preparation- formal fix (10 % neutral buffered formalin) and paraffin enter specimen (FFPE specimens square measure needed). shield paraffin block or slides from uncontrolled heat. Transport tissue block or five unstained (3-micron thick sections), charged slides during a tissue transport kit. (Min: a pair of slides). If causing precut slides, don't over heat it.
Storage/Transport Temperature- At temperature or cold. Transport it in cooled instrumentation throughout weather.
Unacceptable conditions- i) Specimens submitted with non-marked/tagged tissue sort square measure rejected.
ii) Depleted specimens aren't tested.
Stability- i) Ambient: Indefinitely;
ii) Refrigerated: Indefinitely;
iii) Frozen: Unacceptable